|Types of Cancer or Tumors
|Hereditary Breast & Ovarian Cancer Syndrome
|Breast Cancer, Male Breast Cancer
|Early Age Onset (>55):
Other Extracolonic TumorsIn addition:
· Multiple relatives with any Lynch-associated tumors, including colorectal cancer. Examples of other Lynch-associated tumors include those affecting the endometrium, ovaries, stomach, small intestine, kidney, brain or liver.
· Family members diagnosed with cancer at ages that are younger than the average for their type of cancer.
· More than one generation of family affected by a type of cancer.
|Hereditary Leukemia and Hematologic Malignancies Syndromes
Leukemia, Lymphoma, and Multiple Myeloma
Other inherited disorder:
|Familial Adenomatous Polyposis
|Colon Cancer – predisposition for precancerous colon polyps/adenomas, osteomas, desmoids
|Increased risk of developing multiple types of cancers:
soft tissue sarcomas
Adrenal Gland CancerSkin cancer, pancreatic cancer, colon cancer, Testicular cancer, Prostate cancer, Thyroid cancer, kidney cancer
|Von Hippel-Lindau Disease
Multi-System Disorder: abnormal growth of blood vessles/hemangioblastomas/angiomas, Tumors in adrenal glands, kidney, pancreas
|Multiple Endocrine Neoplasias
Medullary Thyroid Cancer and Predisposition to Tumors in Endocrine Glands, Pituitary, Parathyroid, Pancreas,
MEN1: adrenal glands, angiofibromas, meningiomas, ependymomas