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PERSONAL REQUIRED: 1+
FAMILY REQUIRED: 1+

CANCERS MUST BE THE SAME OR BE WITHIN THE SAME POSSIBLE CANCER SYNDROME

Cancer SyndromesTypes of Cancer or Tumors
Hereditary Breast & Ovarian Cancer SyndromeBreast Cancer, Male Breast Cancer
Ovarian Cancer
Prostate Cancer
Pancreatic Cancer
Melanoma
Cowden Syndrome
Lynch SyndromeEarly Age Onset (>55):
Colorectal Cancer
Uterine Cancer
Endometrial Cancer
Other Extracolonic TumorsIn addition:
Family history
·  Multiple relatives with any Lynch-associated tumors, including colorectal cancer. Examples of other Lynch-associated tumors include those affecting the endometrium, ovaries, stomach, small intestine, kidney, brain or liver.
·  Family members diagnosed with cancer at ages that are younger than the average for their type of cancer.
·  More than one generation of family affected by a type of cancer.
Hereditary Leukemia and Hematologic Malignancies Syndromes

Leukemia, Lymphoma, and Multiple Myeloma

Other inherited disorder:
Down syndrome
Bloom syndrome
Klinefelter syndrome
Li-Fraumeni syndrome
ataxia-telangiectasia
neurofibromatosis
Fanconi anemia

Familial Adenomatous PolyposisColon Cancer – predisposition for precancerous colon polyps/adenomas, osteomas, desmoids
Li-Fraumeni SyndromeIncreased risk of developing multiple types of cancers:
soft tissue sarcomas
Breast Cancer
Leukemia
Lung Cancer
Brain Tumors
Adrenal Gland CancerSkin cancer, pancreatic cancer, colon cancer, Testicular cancer, Prostate cancer, Thyroid cancer, kidney cancer
Von Hippel-Lindau Disease

Multi-System Disorder: abnormal growth of blood vessles/hemangioblastomas/angiomas, Tumors in adrenal glands, kidney, pancreas

In addition:
The tumors can also grow in various parts of the body, including:
Adrenal glands, Brain and spinal cord, Eyes, Inner ear, Kidneys, Pancreas, Reproductive tract

Multiple Endocrine Neoplasias

Medullary Thyroid Cancer and Predisposition to Tumors in Endocrine Glands, Pituitary, Parathyroid, Pancreas,

In addition:
Pancreas and digestive tract: Gastrinomas, Insulinomas

MEN1: adrenal glands, angiofibromas, meningiomas,  ependymomas

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